`,nn=function(e){return e?[...new Set(e.map(t=>JSON.stringify(t)))].map(t=>JSON.parse(t)):[]},sa=[],la=async function(e,t){const o=t.filter(i=>sa.some(s=>s.taxon===i)),a=sa.filter(i=>o.includes(i.taxon)),r=t.filter(i=>!o.includes(i));if(r.length){const i=await e.queryLabels(r);if(i.length)return i.forEach(s=>{let{entity:l,label:c}=s;c==="Mammalia"&&(c="Mammalia not otherwise specified");const d={taxon:l,label:c};a.push(d),sa.push(d)}),a}else return a},ca=function(e,t){if(!e||!t)return!1;let o=JSON.stringify(e),a=JSON.stringify(t);return o.indexOf(a)!==-1},Mt=(e,t)=>{const o=e.name??e,a=t.name??t,r=o.toUpperCase(),i=a.toUpperCase();return ri?1:0};let Iy=function(){this.initialise=function(e){this.flatmapAPI=e,this.destinations=[],this.origins=[],this.components=[],this.rawURLs=[],this.controller=void 0,this.uberons=[],this.lookUp=[],this.connectivitySource="map",this.noMapConnectivity=!1},this.createTooltipData=async function(e,t){let o=[];t.feature.hyperlinks&&t.feature.hyperlinks.length>0?o=t.feature.hyperlinks:o=this.rawURLs;let a;if(t.provenanceTaxonomy){a=[];try{const i=await la(e,t.provenanceTaxonomy);i.length&&i.forEach(s=>{const{label:l}=s;a.push(l)})}catch(i){console.log(i)}}return{destinations:this.destinations,origins:this.origins,components:this.components,destinationsWithDatasets:this.destinationsWithDatasets,originsWithDatasets:this.originsWithDatasets,componentsWithDatasets:this.componentsWithDatasets,title:t.label,featureId:t.resource,hyperlinks:o,provenanceTaxonomy:t.provenanceTaxonomy,provenanceTaxonomyLabel:a,connectivitySource:this.connectivitySource,noMapConnectivity:this.noMapConnectivity}},this.updateTooltipData=function(e){return{...e,origins:this.origins,originsWithDatasets:this.originsWithDatasets,components:this.components,componentsWithDatasets:this.componentsWithDatasets,destinations:this.destinations,destinationsWithDatasets:this.destinationsWithDatasets,connectivitySource:this.connectivitySource,noMapConnectivity:this.noMapConnectivity}},this.createComponentsLabelList=function(e,t){let o=[];return e.forEach(a=>{o.push(this.createLabelFromNeuralNode(a[0]),t),a.length===2&&o.push(this.createLabelFromNeuralNode(a[1]),t)}),o},this.createLabelLookup=function(e,t){return new Promise(async o=>{let a={};this.uberons=[];const r=await la(e,t);r.length&&(r.forEach(i=>{const{taxon:s,label:l}=i;a[s]=l,this.uberons.push({id:s,name:l})}),o(a))})},this.buildConnectivitySqlStatement=function(e){let t="select knowledge from knowledge where entity in (";if(e.length===1)t+=`'${e[0]}')`;else if(e.length>1)for(let o in e)t+=`'${e[o]}'${o>=e.length-1?")":","} `;return t},this.buildLabelSqlStatement=function(e){let t="select entity, label from labels where entity in (";if(e.length===1)t+=`'${e[0]}')`;else if(e.length>1)for(let o in e)t+=`'${e[o]}'${o>=e.length-1?")":","} `;return t},this.findAllIdsFromConnectivity=function(e){let t=e.connectivity.flat(),o=[...new Set(t)],a=[];return o.forEach(r=>{Array.isArray(r)?a.push(r.flat()):a.push(r)}),[...new Set(a.flat())]},this.flattenConnectivity=function(e){let t=e.flat(),o=[...new Set(t)],a=[];return o.forEach(r=>{Array.isArray(r)?a.push(r.flat()):a.push(r)}),a.flat()},this.findComponents=function(e,t,o,a){let r=e.connectivity.flat(),i=nn(r),s=[],l=!1;return i.forEach(c=>{l=!1,ca(t,c)&&(l=!0),a&&ca(a,c)&&(l=!0),ca(o,c)&&(l=!0),l||s.push(c)}),s},this.retrieveFlatmapKnowledgeForEvent=async function(e,t){this.controller&&this.controller.abort(),this.controller=new AbortController,this.controller.signal;const o=t.resource;if(this.destinations=[],this.origins=[],this.components=[],this.rawURLs=[],!o||o.length===0||!o[0])return;let a=this.queryForConnectivityNew(e,o[0]);return await Promise.all([a])},this.queryForConnectivityNew=function(e,t,o="map",a=!0){return this.connectivitySource=o,new Promise(r=>{(o==="map"?this.queryMapConnectivity(e.mapMetadata.uuid,t):e.queryKnowledge(t)).then(s=>{if(this.checkConnectivityExists(s)){o==="map"&&(this.noMapConnectivity=!1);let l=s;a?this.processConnectivity(e,l).then(c=>{s.references&&(this.rawURLs=[...s.references]),r(c)}):r(l)}else o==="map"?(this.connectivitySource="sckan",this.noMapConnectivity=!0,e.queryKnowledge(t).then(l=>{if(this.checkConnectivityExists(l)){let c=l;a?this.processConnectivity(e,c).then(d=>{l.references&&(this.rawURLs=[...l.references]),r(d)}):r(c)}else r(!1)}).catch(()=>r(!1))):r(!1)}).catch(s=>{s.name==="AbortError"||console.warn(`Unable to get the knowledge for the entity ${t}.`),r(!1)})})},this.queryMapConnectivity=async function(e,t){const o=this.flatmapAPI+`flatmap/${e}/connectivity/${t}`;try{const a=await fetch(o);if(!a.ok)throw new Error(`Response status: ${a.status}`);return await a.json()}catch(a){throw new Error(a)}},this.queryForConnectivity=function(e,t,o,a=!0){const r={sql:this.buildConnectivitySqlStatement(t)},i={method:"POST",headers:{"Content-Type":"application/json"},body:JSON.stringify(r),...o?{signal:o}:{}};return new Promise(s=>{fetch(`${this.flatmapAPI}knowledge/query/`,i).then(l=>l.json()).then(l=>{if(this.connectivityExists(l)){let c=JSON.parse(l.values[0][0]);a?this.processConnectivity(e,c).then(d=>{s(d)}):s(c)}else s(!1)}).catch(l=>{l.name==="AbortError"||console.error("Error:",l),s(!1)})})},this.checkConnectivityExists=function(e){var t;return e&&((t=e.connectivity)==null?void 0:t.length)},this.connectivityExists=function(e){return!!(e.values&&e.values.length>0&&JSON.parse(e.values[0][0]).connectivity&&JSON.parse(e.values[0][0]).connectivity.length>0)},this.findIfNodeIsSingle=function(e){return e.length===1?(console.error("Server returns a single node",e),e[0]):e.length===2&&e[1].length===0?e[0]:!1},this.createLabelFromNeuralNode=function(e,t){let o=this.findIfNodeIsSingle(e);if(o)return t[o];let a=t[e[0]];return e.length===2&&e[1].length>0&&e[1].forEach(r=>{t[r]==null?a+=`, ${r}`:a+=`, ${t[r]}`}),a},this.flattenAndFindDatasets=function(e,t,o){let a=this.flattenConnectivity(e),r=this.flattenConnectivity(t),i=this.flattenConnectivity(o);this.originsWithDatasets=this.uberons.filter(s=>a.indexOf(s.id)!==-1).sort(Mt),this.componentsWithDatasets=this.uberons.filter(s=>r.indexOf(s.id)!==-1).sort(Mt),this.destinationsWithDatasets=this.uberons.filter(s=>i.indexOf(s.id)!==-1).sort(Mt)},this.processConnectivity=function(e,t){return new Promise(o=>{let a=[],r=[],i;if(t&&t["node-phenotypes"]){const c=["ilxtr:hasSomaLocatedIn"],d=["ilxtr:hasAxonPresynapticElementIn","ilxtr:hasAxonSensorySubcellularElementIn"];c.forEach(f=>{f in t["node-phenotypes"]&&a.push(...t["node-phenotypes"][f])}),a=nn(a),d.forEach(f=>{f in t["node-phenotypes"]&&r.push(...t["node-phenotypes"][f])}),r=nn(r)}else r=nn(t.axons),t.somas&&t.somas.length>0&&a.push(...t.somas),t.dendrites&&t.dendrites.length>0&&a.push(...t.dendrites),a=nn(a),i=t.somas;const s=this.findComponents(t,r,a,i),l=this.findAllIdsFromConnectivity(t);this.createLabelLookup(e,l).then(c=>{this.origins=a.map(d=>this.createLabelFromNeuralNode(d,c)).sort(Mt),this.components=s.map(d=>this.createLabelFromNeuralNode(d,c)).sort(Mt),this.destinations=r.map(d=>this.createLabelFromNeuralNode(d,c)).sort(Mt),this.flattenAndFindDatasets(a,s,r),o({ids:{dendrites:a,components:s,axons:r},labels:{origins:this.origins,components:this.components,destinations:this.destinations}})})})},this.buildPubmedSqlStatement=function(e){let t="select distinct publication from publications where entity in (";if(e.length===1)t+=`'${e[0]}')`;else if(e.length>1)for(let o in e)t+=`'${e[o]}'${o>=e.length-1?")":","} `;return t},this.buildPubmedSqlStatementForModels=function(e){return`select distinct publication from publications where entity = '${e}'`},this.queryKnowledge=async(e,t)=>{const o=`${this.flatmapAPI}/knowledge/query/`,r=await fetch(o,{method:"POST",headers:{Accept:"application/json"},body:JSON.stringify({sql:e,params:t})});if(!r.ok)throw new Error(`Cannot access ${o}`);const i=await r.json();if("error"in i)throw new TypeError(i.error);return i.values}};async function Ty(e){const t=sessionStorage.getItem("flatmap-knowledge");if(t){const r=JSON.parse(t).filter(i=>i.references&&i.references.length).filter(i=>i.references.includes(e));if(r.length)return r.map(s=>s.id)}return[]}async function Ay(e,t,o){const r=`select knowledge from knowledge where source="${da(e)}" and knowledge like "%${t}%" order by source desc`;return(await o.queryKnowledge(r)).map(c=>JSON.parse(c)).map(c=>c.id)}function da(e){return Oy(e.mapMetadata)}function Oy(e){let t="";if(e!=null&&e.connectivity){const o=e.connectivity;"knowledge-source"in o?t=o["knowledge-source"]:"npo"in o&&(t=`${o.npo.release}-npo`)}return t}async function My(e,t){const o=da(e),a=`select knowledge from knowledge where source="${o}" order by source desc`;ps();const 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map.",Fy=e=>{let t={lng:0,lat:0},o;return e.type==="Polygon"?e.coordinates.length&&(o=e.coordinates[0]):o=e.coordinates,o&&(e.type!=="Point"?(o.map(a=>{t.lng+=parseFloat(a[0]),t.lat+=parseFloat(a[1])}),t.lng=t.lng/o.length,t.lat=t.lat/o.length):(t.lng+=parseFloat(o[0]),t.lat+=parseFloat(o[1]))),t},ms=(e,t)=>{const o=[];let a=e.organs?e.organs:e.ftus;const r=a?a.filter((i,s)=>a.findIndex(l=>l.label===i.label)===s):void 0;return r&&r.forEach(i=>{const 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Is.AnnotationService(`${e.flatmapAPI}annotator`)),n.provide("$annotator",t)),{annotator:t}},methods:{enableFeatureResetOnClick:function(e){this.mapImp&&this.mapImp.enableFeatureResetOnClick(e)},setVisibilityFilter:function(e){this.mapImp&&(e?this.mapImp.setVisibilityFilter(e):this.mapImp.clearVisibilityFilter())},manualAbortedOnClose:function(){this.annotationSidebar&&this.$emit("annotation-close"),this.closeTooltip(),this.annotationEventCallback({},{type:"aborted"}),this.initialiseDrawing()},initialiseDrawing:function(){this.connectionEntry={},this.activeDrawTool=void 0,this.activeDrawMode=void 0,this.drawnCreatedEvent={}},cancelDrawnFeature:function(){this.isValidDrawnCreated&&(this.annotationSidebar&&this.$emit("annotation-close"),this.closeTooltip(),this.annotationEntry=[{...this.drawnCreatedEvent.feature,resourceId:this.serverURL}],this.rollbackAnnotationEvent(),this.initialiseDrawing())},connectedFeatureTooltip:function(e){if(this.mapImp)if(e){const t=Number(e);let a={feature:t?this.mapImp.featureProperties(t):{feature:this.existDrawnFeatures.find(r=>r.id===e.trim())}};this.checkAndCreatePopups([a],!1)}else this.closeTooltip()},confirmDrawnFeature:function(){this.isValidDrawnCreated&&(this.checkAndCreatePopups([this.drawnCreatedEvent],!1),Object.keys(this.connectionEntry).length>0&&(this.annotationEntry[0].feature.connection=this.connectionEntry),this.initialiseDrawing())},toolbarEvent:function(e,t){if(!this.isValidDrawnCreated){if(this.manualAbortedOnClose(),this.doubleClickedFeature=!1,this.changeAnnotationDrawMode({mode:"simple_select"}),e==="mode")this.activeDrawMode=t;else if(e==="tool"){if(this.cancelDrawnFeature(),t){const 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o;if(this.offlineAnnotationEnabled)this.offlineAnnotations=JSON.parse(sessionStorage.getItem("anonymous-annotation"))||[],o=this.offlineAnnotations.filter(a=>a.feature&&a.resource===this.serverURL).map(a=>a.feature);else{const a=await this.fetchAnnotatedItemIds(e,t);o=await this.annotator.drawnFeatures(this.userToken,this.serverURL,a),"resource"in o&&(o=o.features)}return o},addAnnotationFeature:async function(){if(this.mapImp){this.featureAnnotationSubmitted||(this.clearAnnotationFeature(),this.loading=!0);const e=this.annotationFrom==="Anyone"?void 0:this.authorisedUser.orcid?this.authorisedUser.orcid:"0000-0000-0000-0000",t=this.annotationFrom==="Anyone"?void 0:this.annotationFrom==="Me",o=await this.fetchDrawnFeatures(e,t);if(this.existDrawnFeatures=o,this.loading=!1,!this.featureAnnotationSubmitted)for(const a of 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t={label:"All",key:"All",children:[]};e.forEach(o=>{const a={colour:o.colour,enabled:o.enabled,label:o.id,key:o.id},r=ms(o,a.key);r.length>0&&(a.children=r),t.children.push(a)}),this.systems.push(t)}},processTaxon:function(e,t){this.taxonConnectivity.length=0,la(this.mapImp,e).then(o=>{o.length&&o.forEach(a=>{let r=!0;t&&(r=t.checkAll?!0:t.checked.includes(a.taxon)),this.taxonConnectivity.push({...a,enabled:r}),this.mapImp&&this.mapImp.enableConnectivityByTaxonIds(a.taxon,r)})})},toggleDrawer:function(){this.drawerOpen=!this.drawerOpen},setColour:function(e){this.colourRadio=e,this.mapImp&&this.mapImp.setPaint({coloured:e,outlined:this.outlinesRadio})},setOutlines:function(e){this.outlinesRadio=e,this.mapImp&&this.mapImp.setPaint({coloured:this.colourRadio,outlined:e})},setInitMapState:function(){if(this.mapImp){const e=this.mapImp.map,t=this.mapImp.options.bounds,o=[[t[0],t[1]],[t[2],t[3]]];e.setMaxBounds(null),e.setRenderWorldCopies(!1),this.initMapState=n.markRaw({initBounds:o})}},resetView:function(){if(this.mapImp){const e=this.mapImp.map,{initBounds:t}=this.initMapState;e.resetNorthPitch({animate:!1}),t&&e.fitBounds(t,{animate:!1}),this.$refs.skcanSelection&&this.$refs.skcanSelection.reset(),this.$refs.layersSelection&&this.$refs.layersSelection.reset(),this.$refs.systemsSelection&&this.$refs.pathwaysSelection.reset(),this.$refs.pathwaysSelection&&this.$refs.pathwaysSelection.reset()}},zoomIn:function(){this.mapImp&&this.mapImp.zoomIn()},zoomOut:function(){this.mapImp&&this.mapImp.zoomOut()},onSelectionsDataChanged:function(e){this.$emit("pathway-selection-changed",e)},sckanSelected:function(e){this.mapImp&&this.mapImp.enableSckanPath(e.key,e.value)},checkAllSCKAN:function(e){this.mapImp&&e.keys.forEach(t=>this.mapImp.enableSckanPath(t,e.value))},zoomToFeatures:function(e){this.mapImp&&this.mapImp.zoomToFeatures(e)},retrieveConnectedPaths:async function(e,t={}){var o,a,r,i,s;if(this.mapImp){let l=[],c=(o=t.target)!=null&&o.length?t.target:[];const d=[...this.mapImp.pathModelNodes(e)],f=await this.mapImp.queryPathsForFeatures(e);if(d.length){if(!c.length){const u=(a=t.type)!=null&&a.length?t.type:["all"],p=await this.flatmapQueries.queryForConnectivityNew(this.mapImp,e[0]),g=(r=p==null?void 0:p.ids)==null?void 0:r.dendrites.flat(1/0),h=(i=p==null?void 0:p.ids)==null?void 0:i.components.flat(1/0),m=(s=p==null?void 0:p.ids)==null?void 0:s.axons.flat(1/0);let y=[];u.includes("origins")&&y.push(...g),u.includes("components")&&y.push(...h),u.includes("destinations")&&y.push(...m),u.includes("all")&&y.push(...g,...h,...m),c=[...new Set(y)]}d.forEach(u=>{this.mapImp.nodePathModels(u).forEach(g=>{const m=this.mapImp.pathModelNodes(g).map(b=>this.mapImp.featureProperties(b).models);c.filter(b=>m.includes(b)).length&&!l.includes(g)&&l.push(g)})})}else f.length&&(c.length?f.forEach(u=>{const g=this.mapImp.pathModelNodes(u).map(m=>this.mapImp.featureProperties(m).models);c.filter(m=>g.includes(m)).length&&!l.includes(u)&&l.push(u)}):l=f);return l=[...new Set([...l,...e])],l}},resetMapFilter:function(){const e=this.mapFilters.alert;let t;const o={"tile-layer":"pathways"},a={NOT:o};e.with&&!e.without?t={OR:[a,{AND:[o,{HAS:"alert"}]}]}:!e.with&&e.without?t={OR:[a,{AND:[o,{NOT:{HAS:"alert"}}]}]}:!e.with&&!e.without&&(t=a),this.setVisibilityFilter(t)},alertMouseEnterEmitted:function(e){if(this.mapImp)if(e.value){let t;const o={"tile-layer":"pathways"},a={NOT:o};if(e.key==="alert"||e.key==="withoutAlert"){const r=e.key==="alert"?{HAS:"alert"}:{NOT:{HAS:"alert"}};t={OR:[a,{AND:[o,r]}]}}this.setVisibilityFilter(t)}else this.resetMapFilter()},alertSelected:function(e){this.mapImp&&(e.key==="alert"?e.value?this.mapFilters.alert.with=!0:this.mapFilters.alert.with=!1:e.key==="withoutAlert"&&(e.value?this.mapFilters.alert.without=!0:this.mapFilters.alert.without=!1),this.resetMapFilter())},checkAllAlerts:function(e){this.mapImp&&(e.value?(this.mapFilters.alert.without=!0,this.mapFilters.alert.with=!0):(this.mapFilters.alert.without=!1,this.mapFilters.alert.with=!1),this.resetMapFilter())},systemSelected:function(e){this.mapImp&&this.mapImp.enableSystem(e.key,e.value)},checkAllSystems:function(e){this.mapImp&&this.systems[0].children.forEach(t=>this.mapImp.enableSystem(t.label,e))},ftuSelected:function(e){this.searchAndShowResult(e,!0,!0)},layersSelected:function(e){this.mapImp&&this.mapImp.enableLayer(e.key,e.value)},checkAllLayers:function(e){this.mapImp&&e.keys.forEach(t=>this.mapImp.enableLayer(t,e.value))},taxonsSelected:function(e){this.mapImp&&this.mapImp.enableConnectivityByTaxonIds(e.key,e.value)},taxonMouseEnterEmitted:function(e){if(this.mapImp)if(e.value){clearTimeout(this.taxonLeaveDelay);let t=this.mapImp.taxonFeatureIds(e.key);this.mapImp.enableConnectivityByTaxonIds(e.key,e.value),this.mapImp.zoomToGeoJSONFeatures(t,{noZoomIn:!0})}else this.taxonLeaveDelay=setTimeout(()=>{this.mapImp.unselectGeoJSONFeatures(),e.selections.forEach(t=>{let o=e.checked.includes(t.taxon);this.mapImp.enableConnectivityByTaxonIds(t.taxon,o)})},1e3)},checkAllTaxons:function(e){this.mapImp&&this.mapImp.enableConnectivityByTaxonIds(e.keys,e.value)},pathwaysSelected:function(e){this.mapImp&&this.mapImp.enablePath(e.key,e.value)},checkAllPathways:function(e){this.mapImp&&e.keys.forEach(t=>this.mapImp.enablePath(t,e.value))},enablePanZoomEvents:function(e){this.mapImp.enablePanZoomEvents(e)},annotationEventCallback:function(e,t){if(t.type==="aborted")this.featureAnnotationSubmitted?this.featureAnnotationSubmitted=!1:this.rollbackAnnotationEvent(),this.annotationEntry=[];else if(t.type==="modeChanged")t.feature.mode==="direct_select"&&(this.doubleClickedFeature=!0),this.annotationSidebar&&t.feature.mode==="simple_select"&&this.activeDrawMode==="Deleted"&&this.annotationEventCallback({},{type:"aborted"});else if(t.type==="selectionChanged"){if(this.selectedDrawnFeature=t.feature.features.length===0?void 0:t.feature.features[0],e.feature.feature=this.selectedDrawnFeature,!this.activeDrawTool)if(this.connectionEntry={},this.selectedDrawnFeature){const o=this.existDrawnFeatures.find(a=>a.id===this.selectedDrawnFeature.id);o&&o.connection&&(this.connectionEntry=o.connection),this.annotationDrawModeEvent(e)}else this.annotationSidebar&&this.previousEditEvent.type==="updated"&&(this.annotationEntry=[{...this.previousEditEvent,resourceId:this.serverURL}],this.annotationEventCallback({},{type:"aborted"})),this.previousEditEvent={}}else{if(t.type==="created"||t.type==="updated"){t.type==="updated"&&t.feature.action&&(t.positionUpdated=t.feature.action==="move");const o=this.mapImp.refreshAnnotationFeatureGeometry(t.feature);e.feature.feature=o}t.type==="created"?this.drawnCreatedEvent=e:this.checkAndCreatePopups([e])}t.type==="updated"&&(this.previousEditEvent=t),t.type==="deleted"?this.previousDeletedEvent=t:this.previousDeletedEvent={}},getTaxons:function(e){let t;return e.taxons&&(typeof e.taxons!="object"?t=JSON.parse(e.taxons):t=e.taxons),t},eventCallback:function(){return(e,t,...o)=>{if(e==="annotation"){const a={feature:t,userData:o,eventType:e};this.annotationEventCallback(a,t)}else if(e==="pan-zoom")this.$emit("pan-zoom-callback",t);else{const a=t.label,r=[t.models],i=this.entry,s=this.biologicalSex,l=t.alert,c=this.getTaxons(t);let d=[{dataset:t.dataset,biologicalSex:s,taxonomy:i,resource:r,label:a,feature:t,userData:o,eventType:e,provenanceTaxonomy:c,alert:l}];if(e==="click"){const f=!t[0];if(!f){d=[];const p=t.mapUUID,g=new Set;for(let[h,m]of Object.entries(t))if(h!=="mapUUID"){const y=m.featureId,b=m.label,C=[m.models],I=this.getTaxons(m);if(g.has(y))continue;g.add(y),d.push({dataset:m.dataset,biologicalSex:s,taxonomy:i,resource:C,label:b,feature:m,userData:o,eventType:e,provenanceTaxonomy:I,alert:m.alert,mapUUID:p})}}const u=f?t:t[0];if(this.setConnectivityDataSource(this.viewingMode,u),this.viewingMode!=="Neuron Connection"){if(this.currentActive=u.models?u.models:"",this.activeDrawTool&&!this.isValidDrawnCreated){const p=u.featureId||this.existDrawnFeatures.find(g=>g.id===u.id);if(this.activeDrawTool==="LineString"&&p){const g=u.featureId?u.featureId:u.id,h=u.label?u.label:`Feature ${u.id}`;this.connectionEntry[` ${g}`]=Object.assign({label:h},Object.fromEntries(Object.entries(u).filter(([m])=>["featureId","models"].includes(m)).map(([m,y])=>[m==="featureId"?"id":m,y])))}}}t&&t.type!=="marker"&&!this.activeDrawTool&&this.checkAndCreatePopups(d)}else e==="mouseenter"&&this.viewingMode!=="Neuron Connection"&&(this.currentHover=t.models?t.models:"");this.$emit("resource-selected",d)}}},setConnectivityDataSource:function(e,t){e==="Exploration"?this.connectivityDataSource=t.models.startsWith("ilxtr:")?t.models:"":this.connectivityDataSource=t.featureId||t.id},changeViewingMode:function(e){e&&(this.viewingMode=e),this.manualAbortedOnClose()},removeActiveTooltips:function(){this.mapImp&&this.mapImp.removePopup(),this.$el.querySelectorAll(".flatmap-tooltip-popup").forEach(t=>t.remove())},createTooltipForConnectivity:function(e,t){const o=document.createElement("div");o.classList.add("flatmap-feature-label"),e.forEach((a,r)=>{const{label:i}=a;if(o.append(qn(i)),r+1{const g=this.mapImp.search(p.id);if(g!=null&&g.results.length){const h=g==null?void 0:g.results[0].featureId;i.push({featureId:h,...p})}else s.push(p)}),i.length){let p=i[0].featureId;this.mapImp.annotations.forEach(g=>{const h=g["anatomical-nodes"];if(h){const m=h.join("");i.every(b=>m.indexOf(b.id)!==-1)&&(p=g.featureId,r.push(p))}}),this.createTooltipForConnectivity(i,p)}else this.removeActiveTooltips();this.emitConnectivityError(s);const l=a.reduce((p,g)=>{const h=this.mapImp.pathways.paths[g],m=h?h.connectivity:null;if(m){const y=m.flat(1/0);p.push(...y)}return p},[]),c=[...new Set(l)],d=[...a,...c],u=[...this.mapImp.modelFeatureIdList(d),...r];this.mapImp.selectGeoJSONFeatures(u)}},showConnectivitiesByReference:function(e){this.searchConnectivitiesByReference(e).then(t=>{this.mapImp.selectFeatures(t)})},searchConnectivitiesByReference:async function(e){const t=sessionStorage.getItem("flatmap-knowledge");let o=[];return t?o=await Ty(e):o=await Ay(this.mapImp,e,this.flatmapQueries),o},getFlatmapKnowledge:function(){let e=[];const t=sessionStorage.getItem("flatmap-knowledge");return t&&(e=JSON.parse(t)),e},emitConnectivityError:function(e){this.$emit("connectivity-error",{data:{errorData:e,errorMessage:Ry}})},checkConnectivityTooltipEntry:function(e){return e!=null&&e.length?e.find(t=>{var o,a;return((o=t==null?void 0:t.destinations)==null?void 0:o.length)||((a=t==null?void 0:t.components)==null?void 0:a.length)})!==void 0:!1},changeConnectivitySource:async function(e){const{entry:t,connectivitySource:o}=e;t.mapId===this.mapImp.id&&(await this.flatmapQueries.queryForConnectivityNew(this.mapImp,t.featureId[0],o),this.tooltipEntry=this.tooltipEntry.map(a=>a.featureId[0]===t.featureId[0]?this.flatmapQueries.updateTooltipData(a):a),this.checkConnectivityTooltipEntry(this.tooltipEntry)&&this.$emit("connectivity-info-open",this.tooltipEntry))},checkAndCreatePopups:async function(e,t=!0){var o;if(this.viewingMode==="Annotation"){const a=e.filter(r=>r.feature).map(r=>r.feature);if(a.length>0)if(this.annotationSidebar&&this.previousDeletedEvent.type==="deleted"&&(this.annotationEntry=[{...this.previousDeletedEvent,resourceId:this.serverURL}],this.annotationEventCallback({},{type:"aborted"})),this.annotationEntry=[],a.forEach(r=>{var i;this.annotationEntry.push({...r,resourceId:this.serverURL,featureId:r.featureId?r.featureId:(i=r.feature)==null?void 0:i.id,offline:this.offlineAnnotationEnabled})}),a[0].feature)this.activeDrawTool||this.activeDrawMode||this.isValidDrawnCreated?(this.featureAnnotationSubmitted=!1,this.activeDrawTool&&this.createConnectivityBody(),this.displayTooltip(a[0].feature.id,Fy(a[0].feature.geometry))):this.rollbackAnnotationEvent();else{const r=this.annotationEntry.filter(i=>i.featureId&&i.models).map(i=>i.models);r.length>0&&this.displayTooltip(r)}else this.annotation={}}else if(this.viewingMode==="Neuron Connection"&&t){const a=e.map(i=>i.resource[0]);if(a.find(i=>!i.startsWith("ilxtr:"))){const i=Array.isArray(a)?[...a]:[a];i.length===1&&i.push([]);const s=(o=e[0].feature)==null?void 0:o.featureId,l=this.mapImp.annotations.get(s),c=l==null?void 0:l["anatomical-nodes"],d=l==null?void 0:l.models;let f,u=i;const p=l==null?void 0:l.models;c!=null&&c.length&&(f=c.find(S=>JSON.parse(S)[0]===d)),f?u=JSON.parse(f):p&&(u=[p,[]]);const g=this.mapImp.knowledgeSource,h=u.flat(1/0),m=[...new Set(h)],b=(await Pt.fetchLabels(this.flatmapAPI,m)).reduce((S,E)=>{const O=E[0],B=JSON.parse(E[1]);return S.push({id:O,label:B.label,source:B.source}),S},[]);b.sort((S,E)=>S.id===E.id?S.source===g&&E.source!==g?-1:S.source!==g&&E.source===g?1:0:S.id.localeCompare(E.id));const C=[];for(let S=0;SO.id===m[S]);E&&C.push(E.label)}const I=qn(C.join(", ")),k={facet:JSON.stringify(u),facetPropPath:`flatmap.connectivity.source.${this.connectionType.toLowerCase()}`,tagLabel:I,term:this.connectionType};this.connectivityFilters.some(S=>S.facet===k.facet&&S.facetPropPath===k.facetPropPath)||this.connectivityFilters.push(k),this.$emit("neuron-connection-feature-click",{filters:this.connectivityFilters,search:""})}else{const i=a.join();this.connectionType.toLowerCase()==="all"&&this.$emit("neuron-connection-feature-click",{filters:[],search:i})}}else{My(this.mapImp,this.flatmapQueries);let a=[];if(this.tooltipEntry=e.filter(r=>r.resource[0]in this.mapImp.pathways.paths).map(r=>({title:r.label,featureId:r.resource,ready:!1})),this.tooltipEntry.length){this.$emit("connectivity-info-open",this.tooltipEntry);for(let i=0;ii.featureId[0]);r.length>0&&this.displayTooltip(r)}}},updateConnectivityFilters:function(e){e.length&&(this.connectivityFilters=e.filter(t=>t.facet.toLowerCase()!=="show all"))},resetConnectivityfilters:function(e){e.length?this.connectivityFilters=this.connectivityFilters.filter(t=>e.some(o=>o.facetPropPath===t.facetPropPath&&o.facet!==t.facet)):this.connectivityFilters=[]},getKnowledgeTooltip:async function(e){const t=await this.flatmapQueries.retrieveFlatmapKnowledgeForEvent(this.mapImp,e);let o=await this.flatmapQueries.createTooltipData(this.mapImp,e);return(t&&t[0]||e.feature.hyperlinks&&e.feature.hyperlinks.length>0)&&(o.featuresAlert=e.alert,o.knowledgeSource=da(this.mapImp),o.mapId=this.mapImp.mapMetadata.id,o.mapuuid=this.mapImp.mapMetadata.uuid),o.ready=!0,o},popUpCssHacks:function(){const e=document.querySelector(".flatmap-tooltip-popup"),t=document.querySelector(".maplibregl-popup-close-button");e&&(e.style.display="none"),t.style.display="block",this.$refs.tooltip.$el.style.display="flex",t.onclick=()=>{this.$emit("connectivity-info-close"),e&&(e.style.display="block")}},closeTooltip:function(){this.$refs.tooltip&&(this.$refs.tooltip.$el.style.display="none"),document.querySelectorAll(".maplibregl-popup").forEach(e=>{e.style.display="none"})},showPopup:function(e,t,o){let a=o;this.mapImp&&(a?a.className||(a.className="custom-popup"):a={className:"custom-popup",positionAtLastClick:!0},this.mapImp.showPopup(e,t,a))},showMarkerPopup:function(e,t,o){this.mapImp&&this.mapImp.showMarkerPopup(e,t,o)},closeMinimap:function(){let e=this.$refs.flatmapContainer.querySelector(".maplibregl-ctrl-minimap");this.minimapSmall?(e.classList.add("enlarge"),e.classList.remove("shrink")):(e.classList.add("shrink"),e.classList.remove("enlarge")),this.minimapSmall=!this.minimapSmall},addResizeButtonToMinimap:function(){let e=this.$refs.flatmapContainer.querySelector(".maplibregl-ctrl-minimap");e&&(this.$refs.minimapResize&&this.$refs.minimapResize.$el.parentNode&&this.$refs.minimapResize.$el.parentNode.removeChild(this.$refs.minimapResize.$el),e.appendChild(this.$refs.minimapResize.$el),this.minimapResizeShow=!0)},setHelpMode:function(e){const t=this.hoverVisibilities.length,o=t-1,a=this.hoverVisibilities[this.helpModeActiveIndex];if(a){const r=a==null?void 0:a.refs,i=a==null?void 0:a.ref,s=this.$refs[r||i];if(s){const{parentElement:l,nextElementSibling:c}=s.$el,d=f=>f&&(f.classList.contains("pathway-container")||f.classList.contains("pathway-location"));(d(l)||d(c))&&(this.requiresDrawer?this.drawerOpen=!0:this.helpModeActiveIndex+=1)}else this.helpModeActiveIndex+=1}e||(this.helpModeActiveIndex=this.helpModeInitialIndex),this.viewingMode!=="Annotation"&&this.helpModeActiveIndex>9&&(this.helpModeActiveIndex=o),e&&this.helpModeActiveIndex>=o&&this.$emit("help-mode-last-item",!0),e&&!this.helpModeDialog?(this.inHelp=!0,this.hoverVisibilities.forEach(r=>{r.value=!0})):e&&this.helpModeDialog&&t>this.helpModeActiveIndex?this.helpModeActiveIndex>-1?(this.closeFlatmapHelpPopup(),setTimeout(()=>{this.inHelp=!1,this.hoverVisibilities.forEach(r=>{r.value=!1}),this.showTooltip(this.helpModeActiveIndex,200)},300)):this.helpModeActiveIndex===-1&&this.openFlatmapHelpPopup():(this.inHelp=!1,this.hoverVisibilities.forEach(r=>{r.value=!1}),this.closeFlatmapHelpPopup())},showTooltip:function(e,t=500){this.inHelp||(clearTimeout(this.tooltipWait[e]),this.tooltipWait[e]=setTimeout(()=>{this.hoverVisibilities[e].value=!0,this.$emit("shown-tooltip")},t))},hideTooltip:function(e,t=500){this.inHelp||(clearTimeout(this.tooltipWait[e]),this.tooltipWait[e]=setTimeout(()=>{this.hoverVisibilities[e].value=!1},t))},displayTooltip:function(e,t=void 0){let o,a={className:"flatmapvuer-popover"};if(t)o=e,a.annotationFeatureGeometry=t,this.annotationEntry.length&&(a.annotationEvent={type:this.annotationEntry[0].type,feature:this.annotationEntry[0].feature});else{const r=Array.isArray(e)?e[0]:e;r&&(o=this.mapImp.modelFeatureIds(r)[0]),this.activeDrawTool||(a.positionAtLastClick=!0)}this.connectivityInfoSidebar&&this.tooltipEntry.length&&this.viewingMode!=="Annotation"&&this.checkConnectivityTooltipEntry(this.tooltipEntry)&&this.$emit("connectivity-info-open",this.tooltipEntry),this.annotationSidebar&&this.viewingMode==="Annotation"&&this.$emit("annotation-open",{annotationEntry:this.annotationEntry,commitCallback:this.commitAnnotationEvent}),o&&!this.disableUI&&(this.viewingMode==="Annotation"&&!this.annotationSidebar||this.viewingMode==="Exploration"&&!this.connectivityInfoSidebar)&&(this.tooltipDisplay=!0,this.$nextTick(()=>{this.mapImp.showPopup(o,this.$refs.tooltip.$el,a),this.popUpCssHacks()}))},moveMap:function(e,t={}){if(this.mapImp){const{offsetX:o=0,offsetY:a=0,zoom:r=4}=t,i=this.mapImp.map,s=this.mapImp.bounds.toArray();this.mapImp.zoomToFeatures(e,{noZoomIn:!0}),this.showPathwaysDrawer(!1),s!=null&&s.length&&setTimeout(()=>{i.fitBounds(s,{offset:[o,a],zoom:r,animate:!0})})}},openFlatmapHelpPopup:function(){if(this.mapImp){let e=this.mapImp.modelFeatureIds("UBERON:0000948");e&&e.length>0&&(this.mapImp.showPopup(e[0],"Click for more information",{anchor:"top",className:"flatmap-popup-popper"}),this.$emit("shown-map-tooltip"))}},closeFlatmapHelpPopup:function(){this.$el.querySelectorAll(".maplibregl-popup-close-button").forEach(e=>{e.click()})},getLabels:function(){let e=[];if(this.mapImp){let t=this.mapImp.annotations;for(let o of t.values())o.label&&e.push(o.label);return Array.from(new Set(e))}},getVisibilityState:function(e){if(["alertSelection","pathwaysSelection","taxonSelection"].forEach(o=>{let a=this.$refs[o];a&&(e[o]=a.getState())}),this.$refs.treeControls){const o=this.$refs.treeControls.$refs.regionTree.getCheckedKeys();e.systemsSelection=o.filter(a=>!a.includes("."))}},setVisibilityState:function(e){["alertSelection","pathwaysSelection","taxonSelection"].forEach(o=>{const a=e[o];if(a){const r=this.$refs[o];r&&r.setState(a)}}),"systemsSelection"in e&&this.$refs.treeControls&&(this.$refs.treeControls.$refs.regionTree.setCheckedKeys(e.systemsSelection),this.systems[0].children.forEach(o=>{this.mapImp.enableSystem(o.key,e.systemsSelection.includes(o.key))}))},getState:function(){if(this.mapImp){let e={entry:this.entry,viewport:this.mapImp.getState()};const t=this.mapImp.getIdentifier();return this.biologicalSex?e.biologicalSex=this.biologicalSex:t&&t.biologicalSex&&(e.biologicalSex=t.biologicalSex),t&&t.uuid&&(e.uuid=t.uuid),e.viewingMode=this.viewingMode,e.searchTerm=this.searchTerm,e.flightPath3D=this.flightPath3DRadio,e.colour=this.colourRadio,e.outlines=this.outlinesRadio,e.background=this.currentBackground,this.offlineAnnotationEnabled&&(e.offlineAnnotations=sessionStorage.getItem("anonymous-annotation")),this.getVisibilityState(e),e}},setState:function(e){e&&(this.mapImp&&e.entry&&this.entry==e.entry&&(!e.biologicalSex||e.biologicalSex===this.biologicalSex)?this.restoreMapState(e):this.createFlatmap(e),this.setStateRequired=!1)},restoreMapState:function(e){if(e){if(e.viewport&&this.mapImp.setState(e.viewport),e.offlineAnnotations&&sessionStorage.setItem("anonymous-annotation",e.offlineAnnotations),e.viewingMode&&this.changeViewingMode(e.viewingMode),"flightPath3D"in e&&this.setFlightPath3D(e.flightPath3D),"colour"in e&&this.setColour(e.colour),"outlines"in e&&this.setOutlines(e.outlines),e.background&&this.backgroundChangeCallback(e.background),e.searchTerm){const t=e.searchTerm;this.searchAndShowResult(t,!0,!0)}this.setVisibilityState(e)}},setFlightPathInfo:function(e){(e===1.6||e>1.6)&&(this.displayFlightPathOption=!0,this.setFlightPath3D(!1))},createFlatmap:function(e){if(!this.mapImp&&!this.loading){this.loading=!0,this.flatmapError=null;let t=!1;this.displayMinimap&&(t={position:"top-right"});let o={taxon:this.entry};this.uuid&&(o.uuid=this.uuid),e?(e.uuid?o={uuid:e.uuid}:e.entry&&(o.taxon=e.entry),e.biologicalSex?o.biologicalSex=e.biologicalSex:o.taxon==="NCBITaxon:9606"&&(o.biologicalSex="PATO:0000384")):this.biologicalSex&&(o.biologicalSex=this.biologicalSex),this.mapManagerRef.loadMap(o,this.eventCallback(),{minZoom:this.minZoom,tooltips:this.tooltips,minimap:t,container:this.$refs.display}).then(r=>{this.mapImp=r,this.serverURL=this.mapImp.makeServerUrl("").slice(0,-1);let i=this.mapImp.details.version;this.setFlightPathInfo(i);const s=this._stateToBeSet?this._stateToBeSet:e;this.onFlatmapReady(s),this.$nextTick(()=>this.restoreMapState(s))}).catch(r=>{var i,s;if(console.error("Flatmap loading error:",r),this.flatmapError={},r.message&&r.message.indexOf("Unknown map")!==-1?(this.flatmapError.title="Unknown Map!",this.flatmapError.messages=Object.keys(o).map(l=>`${l==="uuid"?"UUID":qn(l)}: ${o[l]}`)):(this.flatmapError.title="Error Loading Map!",this.flatmapError.messages=[r.message?r.message:r.toString(),"Please try again later or contact support if the problem persists."]),(s=(i=this.$parent)==null?void 0:i.$refs)!=null&&s.multiContainer){const l=this.$parent;this.flatmapError.button={text:"Load Default Map",callback:()=>{const c=l.initial;l.setSpecies(c,void 0,3)}}}this.loading=!1})}else e&&(this._stateToBeSet={...e},this.mapImp&&!this.loading&&this.restoreMapState(this._stateToBeSet))},computePathControlsMaximumHeight(){const e=this.$refs.display;if(e){const t=getComputedStyle(e),o=parseInt(t.paddingTop)+parseInt(t.paddingBottom),a=e.clientHeight-o;this.pathwaysMaxHeight=a-170}},mapResize:function(){try{this.computePathControlsMaximumHeight(),this.mapImp&&(this.mapImp.resize(),this.showMinimap(this.displayMinimap))}catch{console.error("Map resize error")}},getFilterSources:function(){const e=["kind","taxons"];let t=new Set,o=new Set,a=new Map;for(const i of this.mapImp.annotations.values())if(i.source){"alert"in i?t.add(i.source):o.add(i.source);for(const[s,l]of Object.entries(i))if(e.includes(s)){a.has(s)||a.set(s,new Map);const c=a.get(s),d=f=>{const u=f;c.has(u)||c.set(u,new Set),c.get(u).add(`${i.source}`)};Array.isArray(l)?l.forEach(d):d(l)}}let r={alert:{with:[...t],without:[...o]}};for(const[i,s]of a.entries()){r[i]={};for(const[l,c]of s.entries())r[i][l]=[...c.values()]}return r},getFilterOptions:async function(e,t){const o=t||this.getFlatmapKnowledge(),a=this.pathways;return await 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