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<title>Reproducibility Study for a Computational Model of the Neurovascular Coupling Unit</title>
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Open Access<br>
Reproducible Model<br>
Original Article
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<p>Published: 2023-01-11<br>
Last edited: 2023-01-11</p>
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<h3>Reproducibility Study for a Computational Model of the Neurovascular Coupling Unit</h3>
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<i>
Dempsey, S.
<a href="https://orcid.org/0000-0003-1738-3047"><img class="b" alt="ORCID logo" src="https://orcid.org/sites/default/files/images/orcid_16x16.png" width="16" height="16" /></a>
,
Cedersund, G.
<a href="https://orcid.org/0000-0001-9386-0568"><img class="b" alt="ORCID logo" src="https://orcid.org/sites/default/files/images/orcid_16x16.png" width="16" height="16" /></a>
,
Engström, M.
<a href="https://orcid.org/0000-0002-7221-3430"><img class="b" alt="ORCID logo" src="https://orcid.org/sites/default/files/images/orcid_16x16.png" width="16" height="16" /></a>
,
Talou, G. M.
<a href="https://orcid.org/0000-0002-5208-992X"><img class="b" alt="ORCID logo" src="https://orcid.org/sites/default/files/images/orcid_16x16.png" width="16" height="16" /></a>
,
Safaei, S.
<a href="https://orcid.org/0000-0001-5734-243X"><img class="b" alt="ORCID logo" src="https://orcid.org/sites/default/files/images/orcid_16x16.png" width="16" height="16" /></a>
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<b>To cite this <i>Physiome</i> article, cite the whole collection at the DOI: <a style="color:#580078" href="https://doi.org/10.36903/physiome.21714863" target="_blank" rel="noopener noreferrer">10.36903/physiome.21714863</a>, and the Primary Publication at the DOI: <a style="color:#580078" href="https://doi.org/10.1016/j.neuroimage.2020.116827" target="_blank" rel="noopener noreferrer">https://doi.org/10.1016/j.neuroimage.2020.116827</a>.</b>
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All <i>Physiome</i> articles are published as a collection containing the manuscript as a PDF file and the model implementation as an <a style="color:#580078" href="/faqs.html#omex">OMEX file</a>.
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<b>Primary Publication:</b> <a style="color:#580078" href="https://doi.org/10.1016/j.neuroimage.2020.116827" target="_blank" rel="noopener noreferrer">A quantitative analysis of cell-specific contributions and the role of anesthetics to the neurovascular coupling. 2020</a>
<br>
<br>
<p>
<b>Abstract:</b> The mechanistic model of neurovascular coupling was developed and studied by Sten et al. (2020). This model describes and predicts the arteriolar dilation data of mice under various stimulations while anaesthetised and awake. We reconstructed the model in CellML, using a modular approach for each neuronal pathway, and successfully reproduced the original experiments (see the figures in this article and Sten et al. (2020)). With the success of the result reproduction, the CellML model can now be injected into other OpenCOR workflows to obtain a mechanistic hemodynamic response function of neurovascular coupling arteriolar dilation.</p>
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