Reproducibility Study for a Computational Model of the Neurovascular Coupling Unit

Dempsey, S. , Cedersund, G. , Engström, M. , Talou, G. M. , Safaei, S.

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To cite this Physiome article, cite the whole collection at the DOI: 10.36903/physiome.21714863, and the Primary Publication at the DOI: https://doi.org/10.1016/j.neuroimage.2020.116827. All Physiome articles are published as a collection containing the manuscript as a PDF file and the model implementation as an OMEX file.

Abstract: The mechanistic model of neurovascular coupling was developed and studied by Sten et al. (2020). This model describes and predicts the arteriolar dilation data of mice under various stimulations while anaesthetised and awake. We reconstructed the model in CellML, using a modular approach for each neuronal pathway, and successfully reproduced the original experiments (see the figures in this article and Sten et al. (2020)). With the success of the result reproduction, the CellML model can now be injected into other OpenCOR workflows to obtain a mechanistic hemodynamic response function of neurovascular coupling arteriolar dilation.