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flex: 1 0 auto"> <div class="row"> <head> <title>A theoretical model of slow wave regulation using voltage-dependent synthesis of inositol 1, 4, 5-trisphosphate</title> <style> /* Header/Logo Title */ .header {font-size: 0.8em;} /* Page Content */ .content {} </style> </head> <div class="header"> <div style='float: left;'> Open Access<br> Reproducible Model<br> Original Article </div> <div style='float: right; text-align: right'> <p>Published: 2023-01-20<br> Last edited: 2023-01-23</p> </div> </div> <br> <br> <br> <h3>A theoretical model of slow wave regulation using voltage-dependent synthesis of inositol 1, 4, 5-trisphosphate</h3> <p style='font-size: 1.2em;'> <i> Noroozbabaee, L. <a href="https://orcid.org/0000-0003-0416-1541"><img class="b" alt="ORCID logo" src="https://orcid.org/sites/default/files/images/orcid_16x16.png" width="16" height="16" /></a> , Imtiaz, M. <a href="https://orcid.org/0000-0002-1981-443X"><img class="b" alt="ORCID logo" src="https://orcid.org/sites/default/files/images/orcid_16x16.png" width="16" height="16" /></a> , Helden, D. V. <a href="https://orcid.org/0000-0002-5631-6579"><img class="b" alt="ORCID logo" src="https://orcid.org/sites/default/files/images/orcid_16x16.png" width="16" height="16" /></a> , Du, P. <a href="https://orcid.org/0000-0002-6913-7545"><img class="b" alt="ORCID logo" src="https://orcid.org/sites/default/files/images/orcid_16x16.png" width="16" height="16" /></a> , Nickerson, D. P. <a href="https://orcid.org/0000-0003-4667-9779"><img class="b" alt="ORCID logo" src="https://orcid.org/sites/default/files/images/orcid_16x16.png" width="16" height="16" /></a> </i> </p> <table style="background-color:#E0E0E0;"> <tr style="background-color:#E0E0E0;"> <td> <style> .button { border: 1px solid #580078; background-color: #580078; color: white; padding: 15px 25px; text-align: center; font-size: 16px; vertical-align: middle; cursor: pointer; margin-bottom: 0; width: 13em; height: 100% } .article-icon { max-height: 1.7em; } </style> <a href="https://doi.org/10.36903/physiome.21708176" target="_blank" rel="noopener noreferrer" class="button" > <img class="article-icon" src="/theme/images/Physiome-under.png"> View publication </a> </td> <td> <p> <b>To cite this <i>Physiome</i> article, cite the whole collection at the DOI: <a style="color:#580078" href="https://doi.org/10.36903/physiome.21708176" target="_blank" rel="noopener noreferrer">10.36903/physiome.21708176</a>, and the Primary Publication at the DOI: <a style="color:#580078" href="https://doi.org/10.1016/s0006-3495(02)73952-0" target="_blank" rel="noopener noreferrer">https://doi.org/10.1016/s0006-3495(02)73952-0</a>.</b> </p> <p> All <i>Physiome</i> articles are published as a collection containing the manuscript as a PDF file and the model implementation as an <a style="color:#580078" href="/faqs.html#omex">OMEX file</a>. </p> </td> </tr> </table> <br> <b>Primary Publication:</b> <a style="color:#580078" href="https://doi.org/10.1016/s0006-3495(02)73952-0" target="_blank" rel="noopener noreferrer">A Theoretical Model of Slow Wave Regulation Using Voltage-Dependent Synthesis of Inositol 1,4,5-Trisphosphate. 2002.</a> <br> <br> <p> <b>Abstract:</b> The system of equations and figures presented in Imtiaz et al. (2002) are verified and reproduced in the current curation paper. Here, to demonstrate reproducibility, We describe the model encoded in the CellML and document the differences between our curated model and the one published by Imtiaz et al.. From the primary publication, we extracted data applying the Engauge digitizer software (Mitchell et al., 2020) to compare the current CellML simulation results against those in the primary publication. Editor's note: revised to remove LaTeX code from the abstract.</p> <br> <span><Message><i>Is there something wrong with this publication? </i><a href="mailto:physiome-curators@physiomeproject.org?subject=Query about article 10.36903/physiome.21708176"><i>Contact our curators</i></a>.</Message></span> <br> <br> </div> </div> <script type="text/javascript" src="/theme/js/jquery.js"></script> <script type="text/javascript" src="/theme/js/what-input.js"></script> <script type="text/javascript" src="/theme/js/foundation.min.js"></script> <script> /* When the user clicks on the button, toggle between hiding and showing the dropdown content */ function function_showdropdown_about() { document.getElementById("myDropdown-about").classList.toggle("show"); } function function_showdropdown_authors() { document.getElementById("myDropdown-authors").classList.toggle("show"); } // Close the dropdown if the user clicks outside of it window.onclick = function(event) { if (!event.target.matches('.dropbtn')) { var dropdowns = document.getElementsByClassName("dropdown-container"); var i; for (i = 0; i < dropdowns.length; i++) { var openDropdown = dropdowns[i]; if (openDropdown.classList.contains('show')) { openDropdown.classList.remove('show'); } } } } </script> </body> <!-- Footer with contact info --> <style> footer { flex-shrink: 0; background-color: black; color: white; text-align: center; } </style> <footer> <!-- <span style="display: block; color: white">Contact us: <a style="color:white; text-decoration: underline;" href="mailto:physiome@physiomeproject.org">physiome@physiomeproject.org</a></span> --> <!-- <span style="display: block; color: white">Meet our <a style="color:white; text-decoration: underline" href="/editorial-board.html">Editorial Board</a></span> --> <span style="display: block; colour: white; margin-left:190px">Supported by</span> <p><a href="http://www.iups.org/"><img src="/theme/images/IUPS_white.png" alt="Physiome logo" style="width:7%;height:7%;"></a> <a href="https://www.vph-institute.org/"><img src="/theme/images/Horizonal_Online.png" alt="VPH logo" style="width:13%;height:13%;"></a> <a href="https://www.auckland.ac.nz/en/abi.html"><img src="/theme/images/abi-hc-rgb-white.png" alt="ABI logo" style="width:30%;height:30%;"></a> <a href="https://www.digital-science.com/"><img src="/theme/images/ds-logo-bw.png" alt="Digital Science logo" style="width:15%;height:15%;"></a></p> </footer> <script> (function(i,s,o,g,r,a,m){i['GoogleAnalyticsObject']=r;i[r]=i[r]||function(){ (i[r].q=i[r].q||[]).push(arguments)},i[r].l=1*new Date();a=s.createElement(o), m=s.getElementsByTagName(o)[0];a.async=1;a.src=g;m.parentNode.insertBefore(a,m) })(window,document,'script','https://www.google-analytics.com/analytics.js','ga'); ga('create', 'UA-200859312-1', 'auto'); ga('send', 'pageview'); </script> </html>