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flex: 1 0 auto"> <div class="row"> <head> <title>A kinetic model of beta-adrenergic control in cardiac myocytes</title> <style> /* Header/Logo Title */ .header {font-size: 0.8em;} /* Page Content */ .content {} </style> </head> <div class="header"> <div style='float: left;'> Open Access<br> Reproducible Model<br> Original Article </div> <div style='float: right; text-align: right'> <p>Published: 2021-09-23<br> Last edited: 2021-09-23</p> </div> </div> <br> <br> <br> <h3>A kinetic model of beta-adrenergic control in cardiac myocytes</h3> <p style='font-size: 1.2em;'> <i> Fong, S. <a href="https://orcid.org/0000-0001-8610-1088"><img class="b" alt="ORCID logo" src="https://orcid.org/sites/default/files/images/orcid_16x16.png" width="16" height="16" /></a> , Saucerman, J. J. <a href="https://orcid.org/0000-0001-9464-8374"><img class="b" alt="ORCID logo" src="https://orcid.org/sites/default/files/images/orcid_16x16.png" width="16" height="16" /></a> </i> </p> <table style="background-color:#E0E0E0;"> <tr style="background-color:#E0E0E0;"> <td> <style> .button { border: 1px solid #580078; background-color: #580078; color: white; padding: 15px 25px; text-align: center; font-size: 16px; vertical-align: middle; cursor: pointer; margin-bottom: 0; width: 13em; height: 100% } .article-icon { max-height: 1.7em; } </style> <a href="https://doi.org/10.36903/physiome.16664248" target="_blank" rel="noopener noreferrer" class="button" > <img class="article-icon" src="/theme/images/Physiome-under.png"> View publication </a> </td> <td> <p> <b>To cite this <i>Physiome</i> article, cite the whole collection at the DOI: <a style="color:#580078" href="https://doi.org/10.36903/physiome.16664248" target="_blank" rel="noopener noreferrer">10.36903/physiome.16664248</a>, and the Primary Publication at the DOI: <a style="color:#580078" href="https://doi.org/10.1074/jbc.m308362200" target="_blank" rel="noopener noreferrer">https://doi.org/10.1074/jbc.m308362200</a>.</b> </p> <p> All <i>Physiome</i> articles are published as a collection containing the manuscript as a PDF file and the model implementation as an <a style="color:#580078" href="/faqs.html#omex">OMEX file</a>. </p> </td> </tr> </table> <br> <b>Primary Publication:</b> <a style="color:#580078" href="https://doi.org/10.1074/jbc.m308362200" target="_blank" rel="noopener noreferrer">Modeling β-Adrenergic Control of Cardiac Myocyte Contractility in Silico *. 2003, J.J. Saucerman, L.L. Brunton, A.P. Michailova, A.D. McCulloch</a> <br> <br> <p> <b>Abstract:</b> The system of equations and figures presented in Saucerman et al. (2003) are verified and reproduced in this paper's curation effort. These checks are performed in MATLAB. With some parameter additions and modifications, we can reproduce all figures with small mismatches.</p> <b>References:</b> <p><font size="-1"> 1. Modeling $\beta$-adrenergic control of cardiac myocyte contractility in silico. Journal: Journal of Biological Chemistry. Saucerman, Jeffrey J and Brunton, Laurence L and Michailova, Anushka P and McCulloch, Andrew D. Volume: 278. Year: 2003. <br />2. Cardiac Ca2+ dynamics: the roles of ryanodine receptor adaptation and sarcoplasmic reticulum load. Journal: Biophysical journal. Jafri, M Saleet and Rice, J Jeremy and Winslow, Raimond L. Volume: 74. Year: 1998. <br />3. Excitation-contraction coupling and cardiac contractile force. Bers, Donald. Volume: 237. Year: 2001. <br />4. Density of fat and bone mineral of the mammalian body.. Journal: Metabolism. Mendez, J and Keys, A and Anderson, JT and Grande, F and others. Volume: 9. Year: 1960. <br />5. An Overview of CellML 1.1, a Biological Model Description Language. Journal: SIMULATION. Autumn A. Cuellar and Catherine M. Lloyd and Poul F. Nielsen and David P. Bullivant and David P. Nickerson and Peter J. Hunter. Volume: 79. Year: 2003. <br />6. MATLAB version 9.3.0713579 (R2017b). Year: 2017. <br />7. The matlab ode suite. Journal: SIAM journal on scientific computing. Shampine, Lawrence F and Reichelt, Mark W. Volume: 18. Year: 1997. <br />8. The FAIR Guiding Principles for scientific data management and stewardship. Journal: Scientific data. Wilkinson, Mark D and Dumontier, Michel and Aalbersberg, IJsbrand Jan and Appleton, Gabrielle and Axton, Myles and Baak, Arie and Blomberg, Niklas and Boiten, Jan-Willem and da Silva Santos, Luiz Bonino and Bourne, Philip E and others. Volume: 3. Year: 2016. <br /> </font></p> <br> <span><Message><i>Is there something wrong with this publication? </i><a href="mailto:physiome-curators@physiomeproject.org?subject=Query about article 10.36903/physiome.16664248"><i>Contact our curators</i></a>.</Message></span> <br> <br> </div> </div> <script type="text/javascript" src="/theme/js/jquery.js"></script> <script type="text/javascript" src="/theme/js/what-input.js"></script> <script type="text/javascript" src="/theme/js/foundation.min.js"></script> <script> /* When the user clicks on the button, toggle between hiding and showing the dropdown content */ function function_showdropdown_about() { document.getElementById("myDropdown-about").classList.toggle("show"); } function function_showdropdown_authors() { document.getElementById("myDropdown-authors").classList.toggle("show"); } // Close the dropdown if the user clicks outside of it window.onclick = function(event) { if (!event.target.matches('.dropbtn')) { var dropdowns = document.getElementsByClassName("dropdown-container"); var i; for (i = 0; i < dropdowns.length; i++) { var openDropdown = dropdowns[i]; if (openDropdown.classList.contains('show')) { openDropdown.classList.remove('show'); } } } } </script> </body> <!-- Footer with contact info --> <style> footer { flex-shrink: 0; background-color: black; color: white; text-align: center; } </style> <footer> <!-- <span style="display: block; color: white">Contact us: <a style="color:white; text-decoration: underline;" href="mailto:physiome@physiomeproject.org">physiome@physiomeproject.org</a></span> --> <!-- <span style="display: block; color: white">Meet our <a style="color:white; text-decoration: underline" href="/editorial-board.html">Editorial Board</a></span> --> <span style="display: block; colour: white; margin-left:190px">Supported by</span> <p><a href="http://www.iups.org/"><img src="/theme/images/IUPS_white.png" alt="Physiome logo" style="width:7%;height:7%;"></a> <a href="https://www.vph-institute.org/"><img src="/theme/images/Horizonal_Online.png" alt="VPH logo" style="width:13%;height:13%;"></a> <a href="https://www.auckland.ac.nz/en/abi.html"><img src="/theme/images/abi-hc-rgb-white.png" alt="ABI logo" style="width:30%;height:30%;"></a> <a href="https://www.digital-science.com/"><img src="/theme/images/ds-logo-bw.png" alt="Digital Science logo" style="width:15%;height:15%;"></a></p> </footer> <script> (function(i,s,o,g,r,a,m){i['GoogleAnalyticsObject']=r;i[r]=i[r]||function(){ (i[r].q=i[r].q||[]).push(arguments)},i[r].l=1*new Date();a=s.createElement(o), m=s.getElementsByTagName(o)[0];a.async=1;a.src=g;m.parentNode.insertBefore(a,m) })(window,document,'script','https://www.google-analytics.com/analytics.js','ga'); ga('create', 'UA-200859312-1', 'auto'); ga('send', 'pageview'); </script> </html>