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<title>A Quantitative Model of Human Jejunal Smooth Muscle Cell Electrophysiology</title>
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Open Access<br>
Reproducible Model<br>
Original Article
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<p>Published: 2021-09-09<br>
Last edited: 2021-09-09</p>
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<h3>A Quantitative Model of Human Jejunal Smooth Muscle Cell Electrophysiology</h3>
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Ai, W.
<a href="https://orcid.org/0000-0001-5602-5707"><img class="b" alt="ORCID logo" src="https://orcid.org/sites/default/files/images/orcid_16x16.png" width="16" height="16" /></a>
,
Nickerson, D. P.
<a href="https://orcid.org/0000-0003-4667-9779"><img class="b" alt="ORCID logo" src="https://orcid.org/sites/default/files/images/orcid_16x16.png" width="16" height="16" /></a>
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<b>To cite this <i>Physiome</i> article, cite the whole collection at the DOI: <a style="color:#580078" href="https://doi.org/10.36903/physiome.16590317" target="_blank" rel="noopener noreferrer">10.36903/physiome.16590317</a>, and the Primary Publication at the DOI: <a style="color:#580078" href="https://doi.org/10.1371/journal.pone.0042385" target="_blank" rel="noopener noreferrer">https://doi.org/10.1371/journal.pone.0042385</a>.</b>
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<b>Primary Publication:</b> <a style="color:#580078" href="https://doi.org/10.1371/journal.pone.0042385" target="_blank" rel="noopener noreferrer">A Quantitative Model of Human Jejunal Smooth Muscle Cell Electrophysiology. 2012, Y.C. Poh, A. Corrias, N. Cheng, M.L. Buist</a>
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<b>Abstract:</b> The Poh et al. (2012) paper describes the first biophysically based computational model of human jejunal smooth muscle cell (hJSMC) electrophysiology. The ionic currents are described by either a traditional Hodgkin-Huxley (HH) formalism or a deterministic multi-state Markov (MM) formalism. We create a modularized CellML implementation of the model, which is able to reproduce clamping behaviours of individual currents and whole cell action potential traces. In addition, some inconsistencies have been uncovered and discussed in this paper. EDITOR'S NOTE (v2): A typographical correction in the reproducibility report was made. (v3): This Abstract was appended with a note on changes made to versions.</p>
<b>References:</b>
<p><font size="-1">
1. A quantitative model of human jejunal smooth muscle cell electrophysiology. Poh, Yong Cheng and Corrias, Alberto and Cheng, Nicholas and Buist, Martin Lindsay. Year: 2012. <br />2. A model for human ventricular tissue. Journal: American Journal of Physiology-Heart and Circulatory Physiology. ten Tusscher, Kirsten HWJ and Noble, Denis and Noble, Peter-John and Panfilov, Alexander V. Volume: 286. Year: 2004. <br />3. Single-channel recording. Journal: General Pharmacology: The Vascular System. B. Sakmann and E. Neher. Volume: 27. Year: 1996. <br />4. A quantitative description of membrane current and its application to conduction and excitation in nerve. Journal: The Journal of physiology. Hodgkin, Alan L and Huxley, Andrew F. Volume: 117. Year: 1952. <br />5. Reproducible computational biology experiments with {SED}-{ML} - {The} {Simulation} {Experiment} {Description} {Markup} {Language}. Journal: BMC Systems Biology. Waltemath, Dagmar and Adams, Richard and Bergmann, Frank T. and Hucka, Michael and Kolpakov, Fedor and Miller, Andrew K. and Moraru, Ion I. and Nickerson, David and Sahle, Sven and Snoep, Jacky L. and Novère, Nicolas Le. Volume: 5. Year: 2011. <br />6. {OpenCOR}: a modular and interoperable approach to computational biology. Journal: Front Physiol. Garny, Alan and Hunter, Peter J.. Volume: 6. Year: 2015. <br />7. markummitchell/engauge-digitizer: {Nonrelease}. Year: 2020. <br />
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