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<title>Reproducibility study of the Fabbri et al. 2017 model of the human sinus node action potential</title>
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Open Access<br>
Reproducible Model<br>
Original Article
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<p>Published: 2021-09-01<br>
Last edited: 2021-09-21</p>
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<h3>Reproducibility study of the Fabbri et al. 2017 model of the human sinus node action potential</h3>
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<i>
Ghotli, N. A.
<a href="https://orcid.org/0000-0002-6671-6920"><img class="b" alt="ORCID logo" src="https://orcid.org/sites/default/files/images/orcid_16x16.png" width="16" height="16" /></a>
,
Fabbri, A.
<a href="https://orcid.org/0000-0002-3983-1640"><img class="b" alt="ORCID logo" src="https://orcid.org/sites/default/files/images/orcid_16x16.png" width="16" height="16" /></a>
,
Severi, S.
<a href="https://orcid.org/0000-0003-4306-8294"><img class="b" alt="ORCID logo" src="https://orcid.org/sites/default/files/images/orcid_16x16.png" width="16" height="16" /></a>
,
Garny, A.
<a href="https://orcid.org/0000-0001-7606-5888"><img class="b" alt="ORCID logo" src="https://orcid.org/sites/default/files/images/orcid_16x16.png" width="16" height="16" /></a>
,
Nickerson, D.
<a href="https://orcid.org/0000-0003-4667-9779"><img class="b" alt="ORCID logo" src="https://orcid.org/sites/default/files/images/orcid_16x16.png" width="16" height="16" /></a>
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<b>To cite this <i>Physiome</i> article, cite the whole collection at the DOI: <a style="color:#580078" href="https://doi.org/10.36903/physiome.16550526" target="_blank" rel="noopener noreferrer">10.36903/physiome.16550526</a>, and the Primary Publication at the DOI: <a style="color:#580078" href="https://doi.org/10.1113/jp273259" target="_blank" rel="noopener noreferrer">https://doi.org/10.1113/jp273259</a>.</b>
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All <i>Physiome</i> articles are published as a collection containing the manuscript as a PDF file and the model implementation as an <a style="color:#580078" href="/faqs.html#omex">OMEX file</a>.
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<b>Primary Publication:</b> <a style="color:#580078" href="https://doi.org/10.1113/jp273259" target="_blank" rel="noopener noreferrer">Computational analysis of the human sinus node action potential: model development and effects of mutations. 2017, A. Fabbri, M. Fantini, R. Wilders, S. Severi</a>
<br>
<br>
<p>
<b>Abstract:</b> The sinoatrial node (SAN) is the natural pacemaker of the mammalian heart. It has been the subject of several mathematical studies, aimed at reproducing its electrical response under normal sinus rhythms, as well as under various conditions. Such studies were traditionally done using data from rabbit SAN cells. More recently, human SAN cell data have become available, resulting in the publication of a human SAN cell model (Fabbri et al., 2017), along with its CellML version. Here, we used the CellML file provided by the model authors, together with some SED-ML files and Python scripts that we created to reproduce the main results of the aforementioned modeling study. EDITOR'S NOTE (v2): this article and its OMEX archive are republished with technical changes made to the corresponding Python scripts to remove a run-time error message displayed when executing each simulation.</p>
<b>References:</b>
<p><font size="-1">
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Rebuttal: What If the shoe doesn't fit?“The funny current has a major pacemaking role in the sinus nodeâ€. Journal: Heart Rhythm. Lakatta, Edward G and Maltsev, Victor A. Volume: 9. Year: 2012. <br />16. The case for the funny current and the calcium clock. Journal: Heart Rhythm. Rosen, Michael R and Nargeot, Joel and Salama, Guy. Volume: 9. Year: 2012. <br />17. Modern concepts concerning the origin of the heartbeat. Journal: Physiology. Monfredi, Oliver and Maltsev, Victor A and Lakatta, Edward G. Volume: 28. Year: 2013. <br />18. From two competing oscillators to one coupled-clock pacemaker cell system. Journal: Frontiers in Physiology. Yaniv, Yael and Lakatta, Edward G and Maltsev, Victor A. Volume: 6. Year: 2015. <br />19. New evidence for coupled clock regulation of the normal automaticity of sinoatrial nodal pacemaker cells: Bradycardic effects of ivabradine are linked to suppression of intracellular Ca2+ cycling. Journal: Journal of Molecular and Cellular Cardiology. 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