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<title>Bond Graph Model of Cerebral Circulation: Toward Clinically Feasible Systemic Blood Flow Simulations</title>
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Open Access<br>
Reproducible Model<br>
Original Article
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<p>Published: 2020-08-26<br>
Last edited: 2020-08-26</p>
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<h3>Bond Graph Model of Cerebral Circulation: Toward Clinically Feasible Systemic Blood Flow Simulations</h3>
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<i>
Su, S.
<a href="https://orcid.org/0000-0002-9369-1642"><img class="b" alt="ORCID logo" src="https://orcid.org/sites/default/files/images/orcid_16x16.png" width="16" height="16" /></a>
,
Blanco, P. J.
<a href="https://orcid.org/0000-0001-8402-1092"><img class="b" alt="ORCID logo" src="https://orcid.org/sites/default/files/images/orcid_16x16.png" width="16" height="16" /></a>
,
Müller, L. O.
<a href="https://orcid.org/0000-0003-1933-8995"><img class="b" alt="ORCID logo" src="https://orcid.org/sites/default/files/images/orcid_16x16.png" width="16" height="16" /></a>
,
Hunter, P. J.
<a href="https://orcid.org/0000-0001-9665-4145"><img class="b" alt="ORCID logo" src="https://orcid.org/sites/default/files/images/orcid_16x16.png" width="16" height="16" /></a>
,
Safaei, S.
<a href="https://orcid.org/0000-0001-5734-243X"><img class="b" alt="ORCID logo" src="https://orcid.org/sites/default/files/images/orcid_16x16.png" width="16" height="16" /></a>
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<b>To cite this <i>Physiome</i> article, cite the whole collection at the DOI: <a style="color:#580078" href="https://doi.org/10.36903/physiome.12859424" target="_blank" rel="noopener noreferrer">10.36903/physiome.12859424</a>, and the Primary Publication at the DOI: <a style="color:#580078" href="https://doi.org/10.3389/fphys.2018.00148" target="_blank" rel="noopener noreferrer">https://doi.org/10.3389/fphys.2018.00148</a>.</b>
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<b>Primary Publication:</b> <a style="color:#580078" href="https://doi.org/10.3389/fphys.2018.00148" target="_blank" rel="noopener noreferrer">Bond Graph Model of Cerebral Circulation: Toward Clinically Feasible Systemic Blood Flow Simulations. 2018, Safaei, S., Blanco, P. J., Müller, L. O., Hellevik, L. R. and Hunter, P. J.</a>
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<p>
<b>Abstract:</b> The primary paper Safaei et al. (2018) proposed an anatomically detailed model of the human cerebral circulation that runs faster than real-time on a desktop computer and is designed for use in clinical settings when the speed of response is important. Based on a one-dimensional formulation of the flow of an incompressible fluid in distensible vessels, a lumped parameter model was developed for 218 arterial segments. The proposed model improved simulation speed by approximately 200-fold while preserved accuracy. Bond graph formulation was used to ensure mass and energy conservation. The model predicted the pressure and flow signatures in the body.</p>
<b>References:</b>
<p><font size="-1">
1. Bond Graph Model of Cerebral Circulation: Toward Clinically Feasible Systemic Blood Flow Simulations. Journal: Frontiers in Physiology. Safaei, Soroush and Blanco, Pablo J and Müller, Lucas O and Hellevik, Leif R and Hunter, Peter J. Volume: 9. Year: 2018. <br />2. An anatomically detailed arterial network model for one-dimensional computational hemodynamics.. Journal: IEEE Transactions on Biomedical Engineering. Blanco, Pablo J and Watanabe, Sansuke M and Passos, Marco Aur{\'e}lio RF and Lemos, Pedro A and Feij{\'o}o, Ra{\'u}l A. Volume: 62. Year: 2015. <br />3. Blood flow distribution in an anatomically detailed arterial network model: criteria and algorithms. Journal: Biomechanics and Modeling in Mechanobiology. Blanco, Pablo J and Watanabe, Sansuke M and Dari, Enzo A and Passos, Marco Aur{\'e}lio RF and Feij{\'o}o, Ra{\'u}l A. Volume: 13. Year: 2014. <br />4. A dimensionally-heterogeneous closed-loop model for the cardiovascular system and its applications. Journal: Medical Engineering \& Physics. Blanco, Pablo J and Feij{\'o}o, Ra{\'u}l A. Volume: 35. Year: 2013. <br />
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