Slug: 10.36903/physiome.13034423
DOI: 10.36903/physiome.13034423
SubmissionID: 2e5089b6-61b7-4c5d-beb6-fa4a80e5b89d
ManuscriptID: S000008
Title: Computational Modelling of Glucose Uptake in the Enterocyte
Date: 2020-10-01
SubmissionDate: 2020-09-29
PublishDate: 2020-10-01
LastPublishDate: 2020-10-01
Curator: Anand Rampadarath
Kind: Original Article
PubAuthors: Afshar, N.
Safaei, S.
Nickerson, D. P.
Hunter, P. J.
Suresh, V.
PubAuthorsORCID: 0000-0002-6671-6920
0000-0001-5734-243X
0000-0003-4667-9779
0000-0001-9665-4145
0000-0002-7198-1446
PMRURL: https://models.physiomeproject.org/workspace/572
PrimaryPaperName: Computational Modeling of Glucose Uptake in the Enterocyte. 2019, N. Afshar, S. Safaei, D.P. Nickerson, P.J. Hunter, V. Suresh
PrimaryPaperURL: https://doi.org/10.3389/fphys.2019.00380
FulltextURL: https://physiome.figshare.com/articles/journal_contribution/Computational_Modelling_of_Glucose_Uptake_in_the_Enterocyte/13034423
ArchiveURL: https://physiome.figshare.com/articles/journal_contribution/Computational_Modelling_of_Glucose_Uptake_in_the_Enterocyte/13034423
Abstract: We describe an implemented model of glucose absorption in the enterocyte, as previously published by Afshar et al. Afshar et al. (2019), The model used mechanistic descriptions of all the responsible transporters and was built in the CellML framework. It was validated against published experimental data and implemented in a modular structure which allows each individual transporter to be edited independently from the other transport protein models. The composite model was then used to study the role of the sodium-glucose cotransporter (SGLT1) and the glucose transporter type 2 (GLUT2), along with the requirement for the existence of the apical Glut2 transporter, especially in the presence of high luminal glucose loads, in order to enhance the absorption. Here we demonstrate the reproduction of the figures in the original paper by using the associated model.
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