Slug: 10.36903/physiome.12871070 DOI: 10.36903/physiome.12871070 Title: The cardiac Na+/K+ ATPase: An updated, thermodynamically consistent model Date: 2020-08-27 SubmissionDate: 2020-08-25 PublishDate: 2020-08-27 LastPublishDate: 2020-08-27 Curator: Anand Rampadarath Kind: Retrospective Article PubAuthors: Pan, M. Gawthrop, P. J. Cursons, J. Tran, K. Crampin, E. J. PubAuthorsORCID: 0000-0002-8978-7350 0000-0002-6029-515X 0000-0002-5053-4540 0000-0002-8651-3557 ​ PMRURL: https://models.physiomeproject.org/workspace/4ce PrimaryPaperName: The balance between inactivation and activation of the Na+-K+ pump underlies the triphasic accumulation of extracellular K+ during myocardial ischemia. 2007, Jonna R. Terkildsen, Edmund J. Crampin, and Nicolas P. Smith PrimaryPaperURL: https://doi.org/10.1152/ajpheart.00771.2007 FulltextURL: https://physiome.figshare.com/articles/journal_contribution/The_cardiac_Na_K_ATPase_An_updated_thermodynamically_consistent_model/12871070 ArchiveURL: https://physiome.figshare.com/articles/journal_contribution/The_cardiac_Na_K_ATPase_An_updated_thermodynamically_consistent_model/12871070 Abstract: The Na+/K+ATPase is an essential component of cardiac electrophysiology, maintaining physiological Na+ and K+ concentrations over successive heart beats. Terkildsen et al. (2007) developed a model of the ventricular myocyte Na+/K+ ATPase to study extracellular potassium accumulation during ischaemia, demonstrating the ability to recapitulate a wide range of experimental data, but unfortunately there was no archived code associated with the original manuscript. Here we detail an updated version of the model and provide CellML and MATLAB code to ensure reproducibility and reusability. We note some errors within the original formulation which have been corrected to ensure that the model is thermodynamically consistent, and although this required some reparameterisation, the resulting model still provides a good fit to experimental measurements that demonstrate the dependence of Na+/K+ ATPase pumping rate upon membrane voltage and metabolite concentrations. To demonstrate thermodynamic consistency we also developed a bond graph version of the model. We hope that these models will be useful for community efforts to assemble a whole-cell cardiomyocyte model which facilitates the investigation of cellular energetics. References: 1. Energy-based analysis of biochemical cycles using bond graphs. Journal: Proceedings of the Royal Society of London A: Mathematical, Physical and Engineering Sciences. Gawthrop, Peter J. and Crampin, Edmund J.. Volume: 470. Year: 2014.
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